What is the difference between poly d lysine and poly l lysine

However, poly-D-lysine is nondegradable by such mechanisms. Thus, poly-D-lysine is more convenient with any type of cell line. Poly-D-lysine refers to a type of polylysine produced by the polymerization of D-lysine while poly-L-lysine refers to a type of polylysine produced by the polymerization of L-lysine.

Thus, this is the main difference between poly D lysine and poly L lysine. Another difference between poly D lysine and poly L lysine is that D-lysine rotates the plane-polarized light clockwise while L-lysine rotates the plane-polarized light anticlockwise.

Moreover, poly-D-lysine is more convenient for surface coating while poly-L-lysine is less convenient for surface coating as some cell lines secrete proteases, which can degrade poly-L-lysine.

Hence, this is another important difference between poly D lysine and poly L lysine. Poly-D-lysine is a type of polylysine produced by the polymerization of D-lysine, which is the enantiomer of lysine, rotating the plane-polarized light clockwise.

In comparison, poly-L-lysine is the other type of polylysine produced by L-lysine, the enantiomer of lysine, rotating the plane-polarized light anticlockwise. Though both types of polylysines are used for surface coating of cell culture surfaces to facilitate cell attachment, poly-L-lysine tends to degrade by proteases secreted by several cell lines. Therefore, poly-D-lysine is the convenient form of polylysine for some cell lines.

Hence, the main difference between poly D lysine and poly L lysine is their convenience with cell lines. View all posts. Leave a Reply Cancel reply.

In histochemical applications, both poly-l-lysine and poly-d-lysine are used to coat slides to promote the attachment of cells. Alamanda Polymers offers a number of polylysine products. Feel free to contact us if you have a special request for a poly-l-lysine or poly-d-lysine product that is not listed. Normal precautions exercised in handling laboratory reagents should be followed with handling polylysine. Refer to the product Material Safety Data Sheet for any updated risk, hazard, or safety information.

Observe all local, state, and federal laws when disposing of waste. Otherwise, reagent is stable until expiration date shown on label. Zou, F. Oukacine, T. Le Saux, H.