Similar interactions, possibly leading to exacerbation of the pharmacological action of perazine, may be expected in man. Since the interactions between phenothiazines and tricyclic antidepressants may proceed in two directions, reduced doses of both the neuroleptic and the antidepressant are recommended when the drugs are administered jointly.
Abstract The aim of this study was to search for possible effects of imipramine and amitriptyline on the pharmacokinetics and metabolism of perazine at steady state in rats. Klingensmith : Evaluation of tranquilizing drugs in medical outpatients A controlled study of amobarbital, meprobamate, prochlorperazine, and placebo. Rothman, T. Grayson , and J. Ferguson : A comparative investigation of isocarboxazid and imipramine in depressive syndromes. Wittenborn, J. Plante, F.
Burgess , and H. Maurer : A comparison of imipramine, electroconvulsive therapy and placebo in the treatment of depressions.
Download references. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Snow, L. The controlled evaluation of imipramine and amitriptyline in hospitalized depressed psychiatric patients. Psychopharmacologia 5, — Download citation. Received : 02 October Issue Date : November Anyone you share the following link with will be able to read this content:.
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Products and services. Tricyclic antidepressants and tetracyclic antidepressants Tricyclic and tetracyclic antidepressants affect brain chemicals to ease depression symptoms. By Mayo Clinic Staff. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information. Please try again.
Something went wrong on our side, please try again. Show references Depression: FDA-approved medications may help. Food and Drug Administration. Accessed Aug. Depression basics. National Institute of Mental Health. Revisions to product labeling. Mental health medications. Gabriel M, et al. Antidepressant discontinuation syndrome. Canadian Medical Association Journal. What is pharmacogenomics? Genetics Home Reference.
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West-Ward Pharmaceuticals Corp. Trimipramine prescribing information.
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